Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis | Available online http content 2 3 169 Review The heterotopic tracheal allograft as an animal model of obliterative bronchiolitis David J Hele Magdi H Yacoub and Maria G Belvisi Imperial College School of Medicine London UK Correspondence Maria G Belvisi Department of Cardiothoracic Surgery Imperial College School of Medicine National Heart and Lung Institute Dovehouse Street London SW3 6LY UK. Tel 44 20 7351 8270 fax 44 20 7351 8126 e-mail Received 31 January 2001 Revisions requested 20 February 2001 Revisions received 7 March 2001 Accepted 12 March 2001 Published 5 April 2001 Respir Res 2001 2 169-183 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Heterotopic tracheal allografts in small rodents have been shown to share many characteristics with the development of obliterative bronchiolitis OB in the clinic and therefore provide a suitable animal model for the study of OB. The model facilitates the examination of the pathogenesis of the disease and the elucidation of the cellular and molecular mechanisms involved in its development. The model provides a less technically demanding alternative to whole lung transplantation in small rodents and should lead to a speedier identification of new treatments that might prevent the development of posttransplantation OB in the clinic. Keywords allograft model obliterative bronchiolitis rat trachea Introduction Lung transplantation is the only method currently available to return patients with end-stage pulmonary disease to normal life. The success of lung transplantation has improved since its inception as a result of the introduction of new surgical techniques improved immunosuppressive protocols and innovations in managing acute rejection and infection. The survival rate of recipients is currently 71 at 1 year and 46 at 5 years 1 . The major complication which affects about 50 of patients who survive beyond 3 months is obliterative bronchiolitis OB 2
