Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Recurrent pneumonia with mild hypogammaglobulinemia diagnosed as X-linked agammaglobulinemia in adults | Available online http content 2 3 188 Primary research Recurrent pneumonia with mild hypogammaglobulinemia diagnosed as X-linked agammaglobulinemia in adults Kazuhiro Usui Yoji Sasahara Ryushi Tazawa Koichi Hagiwara Satoshi Tsukada Toshio Miyawaki Shigeru Tsuchiya and Toshihiro Nukiwa Department of Respiratory Oncology and Molecular Medicine Institute of Development Aging and Cancer Tohoku University Sendai Japan Department of Pediatric Oncology Institute of Development Aging and Cancer Tohoku University Sendai Japan Department of Medicine III Osaka University Medical School Osaka Japan Department of Pediatrics Faculty of Medicine Toyama Medical and Pharmaceutical University Toyama Japan Correspondence Ryushi Tazawa MD Department of Respiratory Oncology and Molecular Medicine Institute of Development Aging and Cancer Tohoku University 4-1 Seiryomachi Aoba-ku Sendai 980-8575 Japan. Tel 81 22 717 8539 fax 81 22 717 8549 email ryushi@ Received 29 November 2000 Revisions requested 20 February 2001 Revisions received 6 March 2001 Accepted 12 March 2001 Published 12 April 2001 Respir Res 2001 2 188-192 2001 Usui et al licensee BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Background X-linked agammaglobulinemia XLA is a humoral immunodeficiency caused by disruption of the Bruton s tyrosine kinase BTK gene. Typical XLA patients suffer recurrent and severe bacterial infections in childhood. Methods Flow cytometric analysis of the peripheral monocytes using the anti-BTK antibody was used to characterize a 27 year old male patient with mild hypogammaglobulinemia IgG 635 mg dl IgM 11 mg dl IgA 5 mg dl . He had suffered from frequent pneumonia since age 25 but had no history of frequent infections in his childhood or in adolescence. Sequencing of the BTK cDNA obtained from an Epstein-Barr virus-transformed B lymphoblastoid cell line derived from the bone marrow of the patient was performed to confirm a genetic .
