Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Gene expression in epithelial cells in response to pneumovirus infection. | Available online http content 2 4 225 Review Gene expression in epithelial cells in response to pneumovirus infection Joseph B Domachowske Cynthia A Bonville and Helene F Rosenberg State University of New York Health Upstate Medical University Syracuse New York New York USA Eosinophil Biology Unit Laboratory of Host Defenses NIAID National Institutes of Health Bethesda Maryland USA Correspondence Joseph B Domachowske State University of New York Upstate Medical University Department of Pediatrics 750 East Adams Street Syracuse New York 13210 USA. Tel 1 315 464 7506 fax 1 315 464 7564 e-mail domachoj@ Received 15 December 2000 Revisions requested 15 February 2001 Revisions received 20 March 2001 Accepted 20 April 2001 Published 11 May 2001 Respir Res 2001 2 225-233 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Respiratory syncytial virus RSV and pneumonia virus of mice PVM are viruses of the family Paramyxoviridae subfamily pneumovirus which cause clinically important respiratory infections in humans and rodents respectively. The respiratory epithelial target cells respond to viral infection with specific alterations in gene expression including production of chemoattractant cytokines adhesion molecules elements that are related to the apoptosis response and others that remain incompletely understood. Here we review our current understanding of these mucosal responses and discuss several genomic approaches including differential display reverse transcription-polymerase chain reaction PCR and gene array strategies that will permit us to unravel the nature of these responses in a more complete and systematic manner. Keywords bronchiolitis gene expression pneumonia virus of mice pneumovirus respiratory syncytial virus Introduction RSV and PVM are viruses of the family Paramyxoviridae subfamily pneumovirus they are enveloped singlestranded nonsegmented RNA viruses that can cause intense viral .
