Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Early immune development, atopy and asthma. | Available online http content 2 5 E002 Meeting report Early immune development atopy and asthma insights from ATS 2001 May 18-23 San Francisco Christian H Schroeter and Patricia W Finn Pulmonary Division Brigham and Women s Hospital Boston Massachusetts USA Correspondence Patricia W Finn Pulmonary Division Brigham and Women s Hospital 75 Francis Street Boston MA 02115 USA. Tel 1 617 278 0704 fax 1 617 264 6341 e-mail pwfinn@ Received 11 June 2001 Accepted 13 June 2001 Published 26 June 2001 Respir Res 2001 2 E002 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract There is rising evidence that the initiation of atopy and asthma may occur in early life or even during fetal life. At the American Thoracic Society meeting 2001 in San Francisco multiple reports addressed epidemiological and immunological factors and their influence on the early immune system as well as the development of atopy and asthma. Epidemiologic studies presented at the meeting suggest a protective effect of farming and pet exposure. Early-life exposure to endotoxin a cell wall component of Gram-negative bacteria which can be found in high levels in the presence of pets may have a protective effect. Investigations of the mechanism of the early immune system indicate that mononuclear cord blood cells have the ability to mount a lymphoproliferative response to mitogens and allergens. Reports suggest however that the validity of Th1 Th2 paradigm may need to be scrutinized in early human immune responses particularly regarding the assumption that the neonate immune system is Th2 skewed. The prospective longitudinal follow-up of these studies is promising to give further insight into risk and protective factors in the development in atopy and asthma. Keywords asthma children endotoxin immune response neonatal Introduction Recent evidence suggests that the initiation of atopy and asthma may occur early in life even prenatally. To .
