Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Impact of rhinitis on airway inflammation: biological and therapeutic implications. | Available online http content 2 6 320 Commentary Impact of rhinitis on airway inflammation biological and therapeutic implications Giovanni Passalacqua and Giorgio Walter Canonica Allergy and Respiratory Diseases Department of Internal Medicine University of Genoa Italy Correspondence Giovanni Passalacqua MD Allergy Respiratory Diseases - Department of Internal Medicine Pad. Maragliano L. go R. Benzi 10 Genoa 16132 Italy. Tel 39 010 3538908 fax 39 010 3538904 e-mail gcanonica@ Received 9 May 2001 Revisions requested 26 June 2001 Revisions received 23 July 2001 Accepted 25 July 2001 Published 13 September 2001 Respir Res 2001 2 320-323 2001 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract There is increasing evidence for a close link between the upper and the lower respiratory tracts and the fact that rhinitis has an important impact on asthma. Several clinical and experimental observations suggest a similar immunopathology between the upper and lower airways in allergic subjects. The common inflammatory process that develops in the respiratory tract explains some of the complex interactions among different clinical diseases such as rhinitis sinusitis asthma bronchial hyperresponsiveness and viral infections. There are also non-inflammatory mechanisms that may contribute to the link between rhinitis and asthma. Moreover the outcomes of various pharmacological treatments of rhinitis have recently provided further support for the hypothesis of the united airways. We discuss some of the recent observations on the nose-lung interaction and some of the novel therapeutic approaches used to treat rhinitis and asthma that arise from this. Keywords asthma inflammation rhinitis sinusitis united airways Introduction The overall view of the pathophysiology of respiratory allergy has changed profoundly over the past 10 years. Increasing attention has been devoted to the relationship between rhinitis and asthma . .
