Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" First Siena International Conference on Animal Models of. | Available online http content 3 1 12 Meeting report First Siena International Conference on Animal Models of Chronic Obstructive Pulmonary Disease Certosa di Pontignano University of Siena Italy September 30-October 2 2001 David Hele Respiratory Pharmacology Group Cardiothoracic Surgery Faculty of Medicine Imperial College National Heart and Lung Institute London UK Correspondence David Hele Respiratory Pharmacology Group Cardiothoracic Surgery Faculty of Medicine Imperial College National Heart and Lung Institute Dovehouse Street London SW3 6LY UK. Tel 44 0207 352 8121 ext. 3042 fax 44 0207 351 8126 e-mail Received 9 October 2001 Accepted 25 October 2001 Published 28 November 2001 Respir Res 2002 3 12 2002 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract The meeting proved of great interest to those developing an animal model of chronic obstructive pulmonary disease COPD . COPD is caused by cigarette smoking evidenced by deterioration in lung function. Lung function is only rarely assessed in animal models. A cigarette smoke driven pathology should provide the best in vivo model for COPD. However as lesions produced this way take 8-1 2 months to develop other strategies have to be employed. Emphysematous lesions were also achieved by treatment with elastase lipopolysaccharide ozone and other inducers. Several studies described treatments that have shown activity in these models. Transgenic models were discussed as was the importance of species and strain selection. Keywords animal models COPD cigarette smoke elastase lung function Introduction The meeting was attended by approximately 80 people and was designed to bring together an international group of academic investigators and industrial scientists in a forum that would foster discussion and exchange of ideas. The purpose of the meeting was to assess current animal models of emphysema and COPD and to promote the use of new technologies. The .
