Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Idiopathic pulmonary fibrosis: an epithelial/fibroblastic cross-talk disorder. | Available online http content 3 1 3 Review Idiopathic pulmonary fibrosis an epithelial fibroblastic cross-talk disorder Moisés Selman and Annie Pardo Instituto Nacional de Enfermedades Respiratorias Facultad de Ciencias UNAM México DF México Correspondence Moisés Selman Instituto Nacional de Enfermedades Respiratorias Tlalpan 4502 Col. Sección XVI México DF CP 14080 México. Tel 525 665 0043 fax 525 665 4623 e-mail mselman@ Received 26 July 2001 Revisions requested 17 August 2001 Revisions received 20 August 2001 Accepted 21 August 2001 Published 11 October 2001 Respir Res 2002 3 3 2002 BioMed Central Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract Idiopathic pulmonary fibrosis is a chronic and usually progressive lung disorder of unknown etiology. A growing body of evidence suggests that in contrast to other interstitial lung diseases IPF is a distinct entity in which inflammation is a secondary and non-relevant pathogenic partner. Evidence includes the presence of similar mild moderate inflammation either in early or late disease and the lack of response to potent anti-inflammatory therapy. Additionally it is clear from experimental models and some human diseases that it is possible to have fibrosis without inflammation. An evolving hypothesis proposes that IPF may result from epithelial micro-injuries and abnormal wound healing. Keywords apoptosis epithelial cells extracellular matrix myofibroblasts pulmonary fibrosis Introduction Idiopathic pulmonary fibrosis IPF also referred to as cryptogenic fibrosing alveolitis is a chronic progressive and usually lethal lung disorder of unknown etiology. The disease occurs predominantly from middle age onwards with more than two-thirds of patients being over 60 years old at the time of presentation. Men are nearly twice as likely as women to suffer from IPF 1 . Similar to other interstitial lung diseases IPF has been considered for a long time as the deleterious consequence of an .
