Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: The CRASH trial: the first large-scale, randomised, controlled trial in head injury. | Critical Care December 2001 Vol 5 No 6 Roberts Commentary The CRASH trial the first large-scale randomised controlled trial in head injury Ian Roberts CRASH Trial Management Group CRASH Co-ordinating Centre London School of Hygiene Tropical Medicine London UK Correspondence Ian Roberts Published online 1 October 2001 Critical Care 2001 5 292-293 2001 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract The global epidemic of head injuries is just beginning. Many are caused by road traffic crashes. It is estimated that by 2020 road traffic crashes will have moved from its present position of ninth to third in the world disease burden ranking as measured in disability adjusted life years. In developing countries it will have moved to second. The Corticosteroid Randomisation After Significant Head Injury CRASH trial is a large-scale randomised controlled trial among adults with head injury and impaired consciousness of the effects of a short-term infusion of corticosteroids on death and on neurological disability. Following a successful pilot phase which included over 1000 randomised participants the main phase of the trial is now underway. Over the next 5 years the trial aims to recruit a total of 20 000 patients. Such large numbers will only be possible if hundreds of doctors and nurses can collaborate in emergency departments all over the world. The trial is currently recruiting and new collaborators are welcome to join the trial see . Keywords brain injury emergency medicine head injury injury neurotrauma trauma The global epidemic of head injuries is just beginning. At present over one million people die each year and a similar number are disabled from brain injuries often with profound effects on the quality of life of the affected individuals and their carers 1 . Road traffic crashes account for most of the deaths and car use is rapidly increasing in many countries. It is estimated that by 2020 .
