Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Genetic influences on meningococcal disease. | Critical Care February 2002 Vol 6 No 1 Vermont et al. Review Bench-to-bedside review Genetic influences on meningococcal disease Clementien L Vermont Ronald de Groot and Jan A Hazelzet Sophia Children s Hospital Rotterdam The Netherlands Correspondence Jan A Hazelzet hazelzet@ Published online 26 November 2001 Critical Care 2002 6 60-65 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract This review discusses the possible involvement of a variety of genetic polymorphisms on the course of meningococcal disease. It has been shown that several common genetic polymorphisms can either influence the susceptibility to meningococcal disease or can account for a higher mortality rate in patients. Gene polymorphisms concerning antibody receptors lipopolysaccharide LPS binding receptors or proteins innate complement proteins as well as cytokines and hemostatic proteins are described. The study of genetic polymorphisms might provide important insights in the pathogenesis of meningococcal disease and could make it possible to identify individuals who are at risk of either contrcting or dying from meningococcal disease. Keywords genetic polymorphisms meningococcal sepsis review Neisseria meningitidis is an intracellular Gram-negative diplo-coccus that can cause serious illnesses in children as well as in adults. The spectrum of disease varies from a common cold to life-threatening disorders including meningitis and or a fulminant septic shock. Meningococcal sepsis is characterised by a sudden onset of fever and a petechial or purpuric rash which can be followed by hypotension and multiple organ failure. Mortality rates can be as high as 40 1 . Meningococcal sepsis is characterised by an exceptionally high level of lipopolysaccharide LPS found in blood or cerebrospinal fluid. Additional features of meningococal sepsis include a severe capillary leak syndrome caused by endothelial damage due to circulating mediators neutrophils and platelets and
