Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Toll-like receptors and their role in septic shock. | Available online http content 6 2 125 Review Bench-to-bedside review Toll-like receptors and their role in septic shock Steven M Opal and Christian E Huber1 Professor of Medicine Infectious Disease Division Brown University Medical School Providence Rhode Island USA Research Fellow Infectious Disease Division Brown University Medical School Providence Rhode Island USA Correspondence Steven M Opal Steven_Opal@ Published online 15 February 2002 Critical Care 2002 6 125-136 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract The Toll-like receptors TLRs are essential transmembrane signaling receptors of the innate immune system that alert the host to the presence of a microbial invader. The recent discovery of the TLRs has rapidly expanded our knowledge of molecular events that initiate host-pathogen interactions. These functional attributes of the cellular receptors provide insights into the nature of pattern recognition receptors that activate the human antimicrobial defense systems. The fundamental significance of the TLRs in the generation of systemic inflammation and the pathogenesis of septic shock is reviewed. The potential clinical implications of therapeutic modulation of these recently characterized receptors of innate immunity are also discussed. Keywords CpG motifs sepsis septic shock Toll-like receptors Toll receptors The recent recognition of the TLRs as the principal inducers of the innate immune system is among the most important and fundamental discoveries in microbial pathogenesis in the past decade. This discovery fills an essential gap in our understanding of the molecular events that follow microbial infection and the initial host defense to invasive pathogens. The TLRs are the critical pattern recognition molecules that alert the host to presence of a microbial pathogen 1 2 . The initial engagement of TLRs to specific and highly conserved microbial constituents largely determines the ultimate fate of .
