Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Fulfilling promises of the Human Genome Project. | Critical Care June 2002 Vol 6 No 3 Chiche et al. Review Bench-to-bedside review Fulfilling promises of the Human Genome Project Jean-Daniel Chiche1 Alain Cariou2 and Jean-Paul Mira3 Associate Professor of Critical Care Medicine Medical Intensive Care Unit and Cochin Institute of Molecular Genetics Hôpital Cochin Université René Descartes Paris France 2Associate Professor of Critical Care Medicine Medical Intensive Care Unit Hôpital Cochin Université René Descartes Paris France 3Professor of Critical Care Medicine Medical Intensive Care Unit and Cochin Institute of Molecular Genetics Hôpital Cochin Université René Descartes Paris France Correspondence Jean-Daniel Chiche Published online 20 March 2002 Critical Care 2002 6 212-215 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Since most common diseases have been shown to be influenced by inherited variations in our genes completion of the Human Genome Project and mapping of the human genome single-nucleotide polymorphisms will have a tremendous impact on our approach to medicine. New developments in genotyping techniques and bioinformatics enabling detection of single-nucleotide polymorphisms already provide physicians and scientists with tools that change our understanding of human biology. In the near future studies will relate genetic polymorphisms to features of critical illnesses increased susceptibility to common diseases and altered response to therapy. Novel insights into the contribution of genetic factors to critical illnesses and advances in pharmacogenomics will be used to select the most effective therapeutic agent and the optimal dosage required to elicit the expected drug response for a given individual. Implementation of genetic criteria for patient selection and individual assessment of the risks and benefits of treatment emerges as a major challenge to the pharmaceutical industry. Keywords genetics pharmacogenomics polymorphism In .
