Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Physiological-dose steroid therapy in sepsis [ISRCTN36253388]. | Available online http content 6 3 251 Research Physiological-dose steroid therapy in sepsis ISRCTN36253388 Orhan Yildiz1 Mehmet Doganay2 Bilgehan Aygen2 Muhammet Guven3 Fahrettin Kelestimur4 and Ahmet Tutus5 Consultant Department of Infectious Diseases School of Medicine Erciyes University Kayseri Turkey 2Lecturer Department of Infectious Diseases School of Medicine Erciyes University Kayseri Turkey 3Lecturer Division of Critical Care Department of Internal Medicine School of Medicine Erciyes University Kayseri Turkey 4Lecturer Division of Endocrinology Department of Internal Medicine School of Medicine Erciyes University Kayseri Turkey 5Lecturer Department of Nuclear Medicine School of Medicine Erciyes University Kayseri Turkey Correspondence Orhan Yildiz yildizorhan@ Received 5 October 2001 Revisions requested 5 December 2001 Revisions received 27 January 2002 Accepted 2 April 2002 Published 19 April 2002 Critical Care 2002 6 251-258 2002 Yildiz et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Introduction The aim of the study was to assess the prognostic importance of basal cortisol concentrations and cortisol response to corticotropin and to determine the effects of physiological dose steroid therapy on mortality in patients with sepsis. Methods Basal cortisol level and corticotropin stimulation test were performed within 24 hours in all patients. One group 20 patients received standard therapy for sepsis and physiological-dose steroid therapy for 10 days the other group 20 patients received only standard therapy for sepsis. Basal cortisol level was measured on the 14th day in patients who recovered. The outcome of sepsis was compared. Results Only Sequential Organ Failure Assessment SOFA score was found related to mortality independent from other factors in multivariate analysis. No significant difference was found between the changes in the percentage of SOFA scores of the steroid therapy group and
