Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Immunodepression in the surgical patient and increased susceptibility to infection. | Available online http content 6 4 279 Commentary Immunodepression in the surgical patient and increased susceptibility to infection Hans-Dieter Volk Head Institute of Clinical Immunology Charité Humboldt University Berlin Berlin Germany Correspondence Hans-Dieter Volk Published online 4 July 2002 Critical Care 2002 6 279-281 This article is online at http content 6 4 279 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Multiple organ failure is the major problem in intensive care patients. The failure of the organ immune system is frequently overlooked however. In this issue the article by Angele and Faist provides an excellent review of the topic. Deactivation of monocyte and lymphocyte functions seems to play a key role in post-traumatic immunodepression. To accompany that review we summarize our knowledge of the mechanisms of deactivation. Stress response lipopolysaccharide translocalization and tissue injury contribute to immunoparalysis . Recently developed well standardized assays now allow us to monitor the immune system like other organ functions and opens new approaches for therapeutic interventions. Keywords interleukin-10 immunodepression immunoparalysis monocyte deactivation stress response Sepsis and septic multiple organ failure are leading causes of morbidity and death in critically ill patients. Alterations to the patient s immune system with an excessive systemic inflammatory response on one hand and paralysis of cell-mediated immunity on the other appear to be the key elements in the pathogenesis of multiple organ failure and susceptibility to infection. Thus far immune-based interventions have met with limited success at least in phase III trials. A better understanding of the immunopathogenesis of multiple organ failure is needed if we are to develop new therapeutic strategies. During the past few years our knowledge in the field of sepsis improved through the use of
