Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Glucose production from the kidney. | Available online http content 6 4 317 Review Bench-to-bedside review Glucose production from the kidney Noel Cano Service d Hepatogastroenterologie et Nutrition Clinique Residence du Parc Rue Gaston Berger 13010 Marseille France Correspondence Noel Cano Published online 7 June 2002 Critical Care 2002 6 317-321 This article is online at http content 6 4 317 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X This article is based on a presentation at the Lactate Satellite Meeting held during the 8th Indonesian-International Symposium on Shock Critical Care Bali Indonesia 24 August 2001. Abstract Data obtained from net organ balance studies of glucose production lead to the classic view according to which glucose homeostasis is mainly ensured by the liver and renal glucose production only plays a significant role during acidosis and prolonged starvation. Renal glucose release and uptake as well as the participation of gluconeogenic substrates in renal gluconeogenesis were recently re-evaluated using systemic and renal arteriovenous balance of substrates in combination with deuterated glucose dilution. Data obtained using these methods lead one to reconsider the magnitude of renal glucose production as well as its role in various physiological and pathological circumstances. These findings now conduce one to consider that renal gluconeogenesis substantially participates in postabsorptive glucose production and that its role in glucose homeostasis is of first importance. Keywords Cori cycle glucose homeostasis glutamine hypoglycemia renal gluconeogenesis Data obtained from net organ balance studies of glucose production lead to the classic view according to which glucose homeostasis is mainly ensured by the liver. Hence these studies concluded that renal glucose production only plays a significant role during acidosis and prolonged starvation. These data were not in accordance with some clinical and biochemical
