Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Lactate and the lung. | Available online http content 6 4 327 Review Bench-to-bedside review Lactate and the lung Fulvio Iscra1 Antonino Gullo1 and Gianni Biolo2 1 Department of Surgical Sciences Anaesthesiology and Intensive Care University of Trieste Italy 2Department of Clinical Morphological and Technological Sciences University of Trieste Italy Correspondence Gianni Biolo biolo@ Published online 7 June 2002 Critical Care 2002 6 327-329 This article is online at http content 6 4 327 2002 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X This article is based on a presentation at the Lactate Satellite Meeting held during the 8th Indonesian-International Symposium on Shock Critical Care Bali Indonesia 24 August 2001. Abstract The ability of the isolated lung tissue to take up glucose and to release lactate is potentially similar to that of other body tissues. Nonetheless when lung lactate exchange was assess in vivo in normal humans no measurable lactate production could be detected. Lung lactate production may become clinically evident in disease states especially in the patients with acute lung injury or with acute respiratory distress syndrome. Potential mechanisms of lactate production by the injured lung may include not only the onset of anaerobic metabolism in hypoxic zones but also direct cytokine effects on pulmonary cells and an accelerated glucose metabolism in both the parenchymal and the inflammatory cells infiltrating lung tissue. In addition as skeletal muscle lung tissue may show metabolic adaptations in response to systemic mediators and may contribute to the systemic metabolic response to severe illness even in the absence of direct tissue abnormalities. Keywords acute respiratory distress syndrome arteriovenous balance cytokines lactate release pulmonary artery The respiratory and immune functions of the lung are largely dependent on the activity of a number of metabolic pathways. Surfactants and prostanoids are synthesized .
