Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Changes in the expression of NO synthase isoforms after ozone: the effects of allergen exposure. | Respiratory Research BioMed Central Research Open Access Changes in the expression of NO synthase isoforms after ozone the effects of allergen exposure An-Soo Jang 1 Inseon-S Choi2 Jong-Un Lee3 Sung-Woo Park1 June- Hyuk Lee1 and Choon-Sik Park1 Address Department of Internal Medicine Soonchunhyang University Hospital Bucheon 1174 Jung-dong Wonmi-gu Bucheon-si Gyeonggi-do 420-767 Republic of Korea 2Research Institute of Medical Sciences Department of Internal Medicine Chonnam National University 8 Hak-1-dong Gwangju 501-757 Republic of Korea and 3Physiology Chonnam National University Medical School Chonnam National University 5 Hak-1-dong Gwangju 501-757 Republic of Korea Email An-Soo Jang - jas877@ Inseon-S Choi - ischoi@ Jong-Un Lee - julee@ Sung- Woo Park - swpark@ June-Hyuk Lee - junehyuk@ Choon-Sik Park - mdcspark@ Corresponding author Published 05 June 2004 Received 22 May 2003 Accepted 05 June 2004 Respiratory Research 2004 5 5 This article is available from http content 5 1 5 2004 Jang et al licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Background The functional role of nitric oxide NO and various nitric oxide synthase NOS isoforms in asthma remains unclear. Objective This study investigated the effects of ozone and ovalbumin OVA exposure on NOS isoforms. Methods The expression of inducible NOS iNOS neuronal NOS nNOS and endothelial NOS eNOS in lung tissue was measured. Enhanced pause Penh was measured as a marker of airway obstruction. Nitrate and nitrite in bronchoalveolar lavage BAL fluid were measured using a modified Griess reaction. Results The nitrate concentration in BAL fluid from the OVA-sensitized ozone-exposed OVA-challenged group was greater than that of the
