Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury. | Respiratory Research BioMed Central Research Open Access Proinflammatory role of inducible nitric oxide synthase in acute hyperoxic lung injury Anne-Karin Hesse1 Martina Dorger1 Christian Kupatt2 and Fritz Krombach 1 Address institute for Surgical Research University of Munich Marchioninistr. 15 81366 Munich Germany and 2Department of Internal Medicine I University of Munich Marchioninistr. 15 81366 Munich Germany Email Anne-Karin Hesse - Martina Dorger - doerger@ Christian Kupatt - Fritz Krombach - krombach@ Corresponding author Published 15 September 2004 Received 16 July 2004 Accepted 15 September 2004 Respiratory Research 2004 5 11 doi 1465-9921-5-11 This article is available from http content 5 1 11 2004 Hesse et al licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Hyperoxic exposures are often found in clinical settings of respiratory insufficient patients although oxygen therapy 50 O2 can result in the development of acute hyperoxic lung injury within a few days. Upon hyperoxic exposure the inducible nitric oxide synthase iNOS is activated by a variety of proinflammatory cytokines both in vitro and in vivo. In the present study we used a murine hyperoxic model to evaluate the effects of iNOS deficiency on the inflammatory response. Methods Wild-type and iNOS-deficient mice were exposed to normoxia 60 O2 or 95 O2 for 72 h. Results Exposure to 95 O2 resulted in an increased iNOS mRNA and protein expression in the lungs from wild-type mice. No significant effects of iNOS deficiency on cell differential in bronchoalveolar lavage fluid were observed. However hyperoxia induced a .
