Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Epimorphin expression in interstitial pneumonia. | Respiratory Research BioMed Central Research Open Access Epimorphin expression in interstitial pneumonia Yasuhiro Terasaki 1 3 Yuh Fukuda3 Moritaka Suga2 Naoki Ikeguchi4 and Motohiro Takeya1 Address Department of Cell Pathology Postgraduate School of Medicine Kumamoto University Kumamoto Japan 2Department of Respiratory Medicine Postgraduate School of Medicine Kumamoto University Kumamoto Japan 3Department of Analytic Human Pathology Nippon Medical School Tokyo Japan and 4Osaka R D Laboratory Yokohama-lab Sumitomo Electric Industries Yokohama Japan Email Yasuhiro Terasaki - terayasu@ Yuh Fukuda - fukuda@ Moritaka Suga - suga@ Naoki Ikeguchi - ikeguchi-naoki@ Motohiro Takeya - takeya@ Corresponding author Published 16 January 2005 Received 07 August 2004 Respiratory Research 2005 6 6 doi l465-992l-6-6 Accepted 16 January 2005 This article is available from http content 6 l 6 2005 Terasaki et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Epimorphin modulates epithelial morphogenesis in embryonic mouse organs. We previously suggested that epimorphin contributes to repair of bleomycin-induced pulmonary fibrosis in mice via epithelium-mesenchyme interactions. To clarify the role of epimorphin in human lungs we evaluated epimorphin expression and localization in normal lungs lungs with nonspecific interstitial pneumonia NSIP and lungs with usual interstitial pneumonia UIP we also studied the effect of recombinant epimorphin on cultured human alveolar epithelial cells in vitro. Northern and Western blotting analyses revealed that epimorphin expression in NSIP samples were significantly higher
