Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Marked alveolar apoptosis/proliferation imbalance in end-stage emphysema. | Respiratory Research BioMed Central Research Open Access Marked alveolar apoptosis proliferation imbalance in end-stage emphysema Fiorella Calabrese 1 Cinzia Giacometti11 Bianca Beghe12 Federico Rea13 Monica Loy13 Renzo Zuin12 Giuseppe Marulli13 Simonetta Baraldo12 Marina Saetta12 and Marialuisa Valente11 Address 1Institute of Pathology University of Padua Italy 2Department of Clinical and Experimental Medicine Section of Respiratory Diseases University of Padua Italy and 3Department of Gastroenterological Sciences Section of Thoracic Surgery University of Padua Italy Email Fiorella Calabrese - Cinzia Giacometti - cinziagiacometti@ Bianca Beghe - Federico Rea - Monica Loy - chirtor@ Renzo Zuin - Giuseppe Marulli - Simonetta Baraldo - Marina Saetta - Marialuisa Valente - Corresponding author 1Equal contributors Published 10 February 2005 Respiratory Research 2005 6 14 doi l465-992l-6-l4 Received 29 July 2004 Accepted 10 February 2005 This article is available from http content 6 l 14 2005 Calabrese et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Apoptosis has recently been proposed to contribute to the pathogenesis of emphysema. Methods In order to establish if cell fate plays a role even in end-stage disease we studied 16 lungs 9 smoking-associated and 7 a l antitrypsin AAT -deficiency emphysema from patients who had undergone lung transplantations. Six unused donor lungs served as controls. Apoptosis was evaluated by TUNEL analysis single-stranded DNA .
