Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice. | Respiratory Research BioMed Central Research Open Access Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice Scott C Wesselkamper1 Lung Chi Chen2 and Terry Gordon 2 Address Department of Environmental Health University of Cincinnati Medical Center Cincinnati OH 45267 USA and 2Department of Environmental Medicine New York University School of Medicine Tuxedo NY 10987 USA Email Scott C Wesselkamper - Lung Chi Chen - chenl@ Terry Gordon - gordont@ Corresponding author Published 18 July 2005 Respiratory Research 2005 6 73 doi 1465-9921 -6-73 Received 16 March 2005 Accepted 18 July 2005 This article is available from http content 6 1 73 2005 Wesselkamper et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Individuals may develop tolerance to the induction of adverse pulmonary effects following repeated exposures to inhaled toxicants. Previously we demonstrated that genetic background plays an important role in the development of pulmonary tolerance to inhaled zinc oxide ZnO in inbred mouse strains as assessed by polymorphonuclear leukocytes PMNs macrophages and total protein in bronchoalveolar lavage BAL phenotypes. The BALB cByJ CBy and DBA 2J D2 strains were identified as tolerant and non-tolerant respectively. The present study was designed to identify candidate genes that control the development of pulmonary tolerance to inhaled ZnO. Methods Genome-wide linkage analyses were performed on a CByD2F2 mouse cohort phenotyped for BAL protein PMNs and macrophages following 5 consecutive days of exposure to mg m3 inhaled ZnO for 3 hours day. A haplotype analysis was .
