Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Exhaled 8-isoprostane in childhood asthma. | Respiratory Research BioMed Central Research Open Access Exhaled 8-isoprostane in childhood asthma Sukhbir K Shahid1 Sergei A Kharitonov 1 Nicola M Wilson2 Andrew Bush2 and Peter J Barnes1 Address 1Section of Airway Disease National Heart and Lung Institute Imperial College London London UK and 2Department of Paediatrics Royal Brompton Hospital London UK Email Sukhbir K Shahid - Sergei A Kharitonov - Nicola M Wilson - Andrew Bush - Peter J Barnes - Corresponding author Published 21 July 2005 Received 21 February 2005 Respiratory Research 2005 6 79 doi 1465-9921 -6-79 Accepted 21 July 2005 This article is available from http content 6 1 79 2005 Shahid et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Exhaled breath condensate EBC is a non-invasive method to assess airway inflammation and oxidative stress and may be useful in the assessment of childhood asthma. Methods Exhaled 8-isoprostane a stable marker of oxidative stress was measured in EBC in children 5-17 years with asthma 13 steroid-naive and 12 inhaled steroid-treated and 11 healthy control. Results Mean exhaled 8-isoprostane concentration was significantly elevated in steroid-naive asthmatic children compared to healthy children SEM vs. pg ml p . Children on inhaled steroids also had significantly higher 8-isoprostane levels than those of normal subjects vs. pg ml p . Steroid-naive asthmatics had higher exhaled nitric oxide eNO than those of controls vs. ppb p . eNO in steroid-treated asthmatics was similar to control subjects .
