Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction. | Respiratory Research BioMed Central Research Open Access Role of contractile prostaglandins and Rho-kinase in growth factor-induced airway smooth muscle contraction Dedmer Schaafsma Reinoud Gosens I Sophie T Bos Herman Meurs Johan Zaagsma and S Adriaan Nelemans Address Department of Molecular Pharmacology University of Groningen Antonius Deusinglaan 1 9713 AV Groningen The Netherlands Email Dedmer Schaafsma - Reinoud Gosens - I Sophie T Bos - Herman Meurs - Johan Zaagsma - S Adriaan Nelemans - Corresponding author Published 27 July 2005 Received 13 May 2005 Respiratory Research 2005 6 85 doi 1465-9921 -6-85 Accepted 27 July 2005 This article is available from http content 6 1 85 2005 Schaafsma et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In addition to their proliferative and differentiating effects several growth factors are capable of inducing a sustained airway smooth muscle ASM contraction. These contractile effects were previously found to be dependent on Rho-kinase and have also been associated with the production of eicosanoids. However the precise mechanisms underlying growth factor-induced contraction are still unknown. In this study we investigated the role of contractile prostaglandins and Rho-kinase in growth factor-induced ASM contraction. Methods Growth factor-induced contractions of guinea pig open-ring tracheal preparations were studied by isometric tension measurements. The contribution of Rho-kinase mitogen-activated protein kinase MAPK and cyclooxygenase COX to these reponses was established using the inhibitors Y-27632 1 pM U-0126 3 pM and .
