Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú y đề tài: Transfer of immunoglobulins through the mammary endothelium and epithelium and in the local lymph node of cows during the initial response after intramammary challenge with E. coli endotoxin. | Acta Veterinaria Scandinavica BioMed Central Research Transfer of immunoglobulins through the mammary endothelium and epithelium and in the local lymph node of cows during the initial response after intramammary challenge with E. coli endotoxin Karin Ostensson 1 and Shichun Lun2 Open Access Address Department of Clinical Sciences Division of Reproduction Faculty of Veterinary Medicine and Animal Science Swedish University of Agricultural Sciences Uppsala Sweden and 2Department of Medicine Johns Hopkins University School of Medicine Baltimore USA Email Karin Ostensson - Shichun Lun - slun1@ Corresponding author Published 2 July 2008 Received 3 April 2008 Acta Veterinaria Scandinavian 2008 50 26 doi 1751-0147-50-26 Accepted 2 July 2008 This article is available from http content 50 1 26 2008 Ostensson and Lun licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The first hours after antigen stimulation interactions occur influencing the outcome of the immunological reaction. Immunoglobulins originate in blood and or are locally synthesized. The transfer of Ig isotypes Igs in the udder has been studied previously but without the possibility to distinguish between the endothelium and the epithelium. The purpose of this study was to map the Ig transfer through each barrier separately and Ig transfer in the local lymph nodes of the bovine udder during the initial innate immune response. Methods The content of IgGI IgG2 IgM IgA and albumin BSA was examined in peripheral afferent mammary lymph and lymph leaving the supramammary lymph nodes and in blood and milk before 0 h and during 4 hours after intramammary challenge with Esherichia coli endotoxin in 5
