Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú yđề tài: Effect of a povidone-iodine intrauterine infusion on progesterone levels and endometrial steroid receptor expression in mares. | Kalpokas et al. Acta Veterinaria Scandinavica 2010 52 66 http content 52 1 66 AVS ACTAVETERINARIA SCANDINAVICA RESEARCH Open Access Effect of a povidone-iodine intrauterine infusion on progesterone levels and endometrial steroid receptor expression in mares Irnmm I rsrslrxì c 11-om Cl Porrlir ir ici1 Prsrlrslfrs Pix orrs2 K drilind Tdlmrsn2 C .xtxd Cxxrtrsrm3 O .irrxlirx .i irSrxldc4 Iiene Kalpokas reinando reidigon Rodolio Riveio Maillina lalmon Isabel oaitoie Caiolllia Vllioles Abstract Background Intrauterine infusions have been widely used for the treatment of endometritis in the mare. Nevertheless their consequences on endocrine and endometrial molecular aspects are unknown. We studied the effect of a 1 povidone-iodine solution intrauterine infusion on progesterone levels endometrial histology and estrogen ERa and progesterone PR receptor distribution by immunohistochemistry. Methods Fourteen healthy mares were used in this study. Estruses were synchronized and seven mares were treated with intrauterine infusions at days 0 and 2 post ovulation of two consecutive estrous cycles. Uterine biopsy samples were taken on days 6 and 15 post ovulation. Results The treatment did not induce an inflammatory response indicating endometritis neither affected the ERa. However it reduced the percentage of PR positive cells PPC on day 6 deep glandular epithelium control vs. infused P . Treated mares tended to have lower progesterone levels on day 2 ng ml vs. ng ml P and higher levels on day 15 compared with controls ng ml vs. ng ml P . Conclusion a 1 povidone-iodine infusion during days 0 and 2 post ovulation in healthy mares did not induce histological changes indicating endometritis but altered progesterone concentrations and reduced the expression of endometrial PR at day 6 without affecting the ERa. These changes could reduce embryo survival. Background Endometritis is a major cause of infertility in the mare 1
