Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú yđề tài: Evaluation of adverse effects in tamoxifen exposed healthy female dogs. | Tavares et al. Acta Veterinaria Scandinavica 2010 52 67 http content 52 1 67 AVS ACTAVETERINARIA tUnZZ 10 SCANDINAVICA RESEARCH Open Access Evaluation of adverse effects in tamoxifen exposed healthy female dogs 12 11 1 Wanessa LF Tavares Gleidice E Lavalle Mariana S Figueiredo Aline G Souza Angelica C Bertagnolli Fernando AB Viana2 Paulo RO Paes3 Rubens A Carneiro3 Guilherme AO Cavalcanti2 Marilia M Melo3 Geovanni D Cassali1 Abstract Background Mammary tumors are among the most frequent neoplasms in female dogs but the strategies employed in animal treatment are limited. In human medicine hormone manipulation is used in cancer therapy. Tamoxifen citrate is a selective inhibitor of oestrogen receptors and exerts a potent anti-oestrogen effect on the mammary gland. The aim of this study was to evaluate the adverse effects when exposing healthy female dogs to tamoxifen. Methods Tamoxifen was administered for 120 days at a dose of or mg kg day to either intact or spayed female dogs. The effects were assessed through clinical examination haematology serum biochemistry ophthalmology and bone marrow aspirate examination. Ovariohysterectomy was performed and the uterus examined by histopathology. Results Vulva oedema and purulent vaginal discharge developed with 10 days of tamoxifen exposure in all groups. Pyometra was diagnosed after around 90 days of exposure in intact females with frequencies increasing during the following 30 days of exposure. Up to 50 of dogs within the groups developed retinitis but none of the dogs had signs of reduced visual acuity. The prevalence of retinitis in each group was similar after 120 days of exposure. Haematological biochemical and bone marrow changes were not observed. Due to the high risk of developing pyometra after prolonged exposure to tamoxifen only spayed animals should be given this medication. Conclusions A dose of mg tamoxifen kg body weight day is recommended when treating tamoxifenresponsive
