Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Bovine colostrum in oral treatment of enterogenic endotoxaemia in rats. | Critical Care December 2002 Vol 6 No 6 Dohler et al. Research Open Access Bovine colostrum in oral treatment of enterogenic endotoxaemia in rats J Rudiger Dohler1 and Lars Nebermann2 1 Head Department of Orthopaedic Trauma and Hand Surgery Klinikum Plau am See Mecklenburg-Vorpommern Germany 2Lieutenant Commander German Navy former Postgraduate Research Fellow Department of Experimental Surgery University Hospital of Kiel Schleswig-Holstein Germany Correspondence J Rudiger Dohler doehler@ Received 11 February 2002 Revisions requested 7 May 2002 Revisions received 7 August 2002 Accepted 30 August 2002 Published 25 September 2002 Critical Care 2002 6 536-539 DOI cc1819 This article is online at http content 6 6 536 2002 Dohler et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X . This article is published in Open Access verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose provided this notice is preserved along with the article s original URL. Abstract Introduction Under conditions of shock bacteria and endotoxins in the intestines can traverse the mucosal barrier by translocation and enter the blood and lymphatic system. Immunoglobulins and lactoferrin have been reported to neutralize endotoxins and bacteria. We studied the essential therapeutic factors of colostrum products in an animal experiment. Method We simulated endotoxaemia by per-oral administration of a suspension of Escherichia coli and antibiotics into the duodenum of anaesthetized rats after giving intraperitoneal carrageenan. At the same time pure bovine colostrum or lactoferrin-enriched bovine colostrum was given. Therapeutic effects were studied by examining plasma endotoxin activity and bacterial contamination of mesenterial lymph nodes and peritoneal lavages. Albumin was used in a control group. Results The most effective bovine colostrum was able to reduce the maximum plasma .
