Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Science review: Mechanisms of ventilator-induced injury. | Available online http content 7 3 233 Review Science review Mechanisms of ventilator-induced injury James A Frank1 and Michael A Matthay2 1Assistent Professor of Medicine Division of Pulmonary and Critical Care Medicine University of California San Francisco Cardiovascular Research Institute San Francisco California USA 2Professor of Medicine Division of Pulmonary and Critical Care Medicine and the Department of Anesthesia University of California San Francisco Cardiovascular Research Institute San Francisco California USA Correspondence James A Frank frankja@ Published online 16 October 2002 Critical Care 2003 7 233-241 DOI cc1829 This article is online at http content 7 3 233 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Acute respiratory distress syndrome ARDS and acute lung injury are among the most frequent reasons for intensive care unit admission accounting for approximately one-third of admissions. Mortality from ARDS has been estimated as high as 70 in some studies. Until recently however no targeted therapy had been found to improve patient outcome including mortality. With the completion of the National Institutes of Health-sponsored Acute Respiratory Distress Syndrome Network low tidal volume study clinicians now have convincing evidence that ventilation with tidal volumes lower than those conventionally used in this patient population reduces the relative risk of mortality by 21 . These data confirm the long-held suspicion that the role of mechanical ventilation for acute hypoxemic respiratory failure is more than supportive in that mechanical ventilation can also actively contribute to lung injury. The mechanisms of the protective effects of low tidal volume ventilation in conjunction with positive end expiratory pressure are incompletely understood and are the focus of ongoing studies. The objective of the present article is to review the potential cellular mechanisms of lung
