Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Clinical review: Fever in intensive care unit patients. | Available online http content 7 3 221 Review Clinical review Fever in intensive care unit patients Michael Ryan1 and Mitchell M Levy2 1 Fellow Brown Medical School Rhode Island Hospital Pulmonary Critical Care Division Providence Rhode Island USA 2Associate Professor Brown Medical School Rhode Island Hospital and Medical Director of MICU Rhode Island Hospital Pulmonary Critical Care Division Providence Rhode Island USA Correspondence Mitchell M Levy Published online 8 March 2003 Critical Care 2003 7 221-225 DOI cc1879 This article is online at http content 7 3 221 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Fever is a common response to sepsis in critically ill patients. Fever occurs when either exogenous or endogenous pyrogens affect the synthesis of prostaglandin E2 in the pre-optic nucleus. Prostaglandin E2 slows the rate of firing of warm sensitive neurons and results in increased body temperature. The febrile response is well preserved across the animal kingdom and experimental evidence suggests it may be a beneficial response to infection. Fever however is commonly treated in critically ill patients usually with antipyretics without good data to support such a practice. Fever induces the production of heat shock proteins HSPs a class of proteins critical for cellular survival during stress. HSPs act as molecular chaperones and new data suggest they may also have an anti-inflammatory role. HSPs and the heat shock response appear to inhibit the activation of NF-kP thus decreasing the levels of proinflammatory cytokines. The anti-inflammatory effects of HSPs coupled with improved survival of animal models with fever and infection call into question the routine practice of treating fever in critically ill patients. Keywords fever heat shock proteins intensive care unit nuclear factor-KB sepsis Fever occurs commonly in hospitalized patients. It is estimated that nosocomial .
