Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Clinical review: Extracorporeal blood purification in severe sepsis. | Available online http content 7 2 139 Review Clinical review Extracorporeal blood purification in severe sepsis Ramesh Venkataraman1 Sanjay Subramanian2 and John A Kellum3 Visiting Instructor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2Staff Intensivist Department of Medicine Musselshell Medical Center Roundup Montana USA 3Associate Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Correspondence John A Kellum kellumja@ Published online 21 February 2003 Critical Care 2003 7 139-145 DOI cc1889 This article is online at http content 7 2 139 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Sepsis and septic shock are the leading causes of acute renal failure multiple organ system dysfunction and death in the intensive care unit. The pathogenesis of sepsis is complex and comprises a mosaic of interconnected pathways. Several attempts to improve patient outcomes by targeting specific components of this network have been unsuccessful. For these reasons the ideal immunomodulating strategy would be one that restores immunologic stability rather than blindly inhibiting or stimulating one or another component of this complex network. Hence the recent focus of immunomodulatory therapy in sepsis has shifted to nonspecific methods of influencing the entire inflammatory response without suppressing it. Here we discuss the various modalities of extracorporeal blood purification the existing evidence and future prospects. Keywords continuous renal replacement therapy hemo-adsorption hemofiltration high-flux dialysis high-volume hemofiltration Extracorporeal therapies designed to remove substances from the circulation now include hemodialysis hemofiltration hemoadsorption plasma filtration cell-based therapies and combinations of any of these. In recent years there have been .
