Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về y học đề tài: Science review: Genetic variability in the systemic inflammatory response. | Critical Care August 2003 Vol 7 No 4 Waterer and Wunderink Review Science review Genetic variability in the systemic inflammatory response Grant W Waterer1 and Richard G Wunderink2 1Senior Lecturer in Medicine Department of Medicine University of Western Australia Australia 2Director Research Department Methodist Le Bonheur Healthcare Memphis and Clinical Associate Professor University of Tennessee Memphis Tennessee USA Correspondence Richard G Wunderink wunderir@ Published online 4 April 2003 Critical Care 2003 7 308-314 DOI cc2164 This article is online at http content 7 4 308 2003 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract The present review discusses recent studies that have identified genetic differences in inflammatory proteins associated with different phenotypic presentations of systemic inflammation. Basic genetic terminology is defined. Implications of genetic influences on the inflammatory response are discussed. The published associations of specific polymorphisms in antigen recognition pathways proinflammatory cytokines anti-inflammatory cytokines and effector molecules are reviewed. The strongest and most consistent associations thus far have been with the tumor necrosis factor lymphotoxin-a and IL-1 receptor antagonist polymorphisms. However large phenotypically detailed studies are required to address all of the other potential polymorphisms in inflammatory molecule genes and their interactions. Keywords gene polymorphisms genetics inflammation pneumonia sepsis The fact that individual genetic differences impact on the risk for developing or dying from various diseases has long been accepted. Typical examples include sickle cell trait and malaria BRCA2 mutations and breast carcinoma and trinucleotide repeats and a variety of neurologic diseases including Huntington disease. Physicians have also long been aware of the markedly different responses of seemingly similar individuals to .
