Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Following severe injury, hypocholesterolemia improves with convalescence but persists with organ failure or onset of infection. | Available online http content 7 6 R145 Research Open Access Following severe injury hypocholesterolemia improves with convalescence but persists with organ failure or onset of infection C Michael Dunham1 Michael H Fealk2 and Wilbur E Sever III2 Assistant Director Trauma Critical Care Services St. Elizabeth Health Center Youngstown Ohio USA 2Trauma Critical Care Services St. Elizabeth Health Center Youngstown Ohio USA Correspondence C Michael Dunham Michael_Dunham@ Received 17 March 2003 Revisions requested 13 June 2003 Revisions received 18 August 2003 Accepted 21 August 2003 Published 1 October 2003 Critical Care 2003 7 R145-R153 DOI cc2382 This article is online at http content 7 6 R145 2003 Dunham et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Introduction Our primary objective was to determine the impact of traumatic injury onset of infection organ metabolic dysfunction and mortality on serum cholesterol. Methods During 676 surgical intensive care unit SICU days 28 ventilated trauma patients underwent daily measurement of white blood cell WBC count and differential cholesterol arterial oxygen tension fractional inspired oxygen bilirubin glucose creatinine and bicarbonate. With the onset of infection WBC response was considered positive if the WBC count was or greater immature neutrophils were 10 or greater or WBC count increased by 20 . Cholesterol response was considered positive if cholesterol decreased or failed to increase by 10 . Results Injury Severity Score was and there were 48 infections. Initial cholesterol was decreased 119 44mg dl compared with expected values from a database 201 1 7 mg dl P . The 25 survivors had higher cholesterol at SICU discharge .
