Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment. | Available online http content 8 1 R21 Research Open Access Offset of pharmacodynamic effects and safety of remifentanil in intensive care unit patients with various degrees of renal impairment Des Breen1 Alexander Wilmer2 Andrew Bodenham3 Vagn Bach4 Jan Bonde5 Paul Kessler6 Sven Albrecht7 and Soraya Shaikh8 Consultant in Anaesthesia and Intensive Care ICU Royal Hallamshire Hospital Sheffield UK 2Associate Professor of Medicine MICU UZ Gasthuisberg Leuven Belgium 3Consultant in Anaesthesia and Intensive Care ICU Leeds General Infirmary Leeds UK 4Director of Intensive Care Hillerod Syngehus Hillerod Denmark 5Consultant in Intensive Care Amtssygehuset i Herlev Herlev Denmark 6Assistant Professor of Anaesthesiology ICU J-W Goethe Universitat Klinik fuer Anaesthesiologie Frankfurt Germany 7Professor and Vice Chairman ICU Universitat Erlangen-Nurnberg Klinik fur Anaesthesiologie Erlangen Germany 8Global Study Manager GlaxoSmithKline R D Greenford UK Correspondence Des Breen Received 2 October 2003 Accepted 16 October 2003 Published 21 November 2003 Critical Care 2004 8 R21-R30 DOI cc2399 This article is online at http content 8 1 R21 2004 Breen et al. licensee BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Introduction This open label multicentre study was conducted to assess the times to offset of the pharmacodynamic effects and the safety of remifentanil in patients with varying degrees of renal impairment requiring intensive care. Methods A total of 40 patients who were aged 18 years or older and had normal mildly impaired renal function estimated creatinine clearance 50ml min n 10 or moderate severe renal impairment estimated creatinine clearance 50ml min n 30 were entered into the study. .
