Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Inhaled nitric oxide: another weapon in our armamentarium in the battle against acute hypoxic respiratory failure in preterm infants. | Available online http content 8 2 77 Commentary Inhaled nitric oxide another weapon in our armamentarium in the battle against acute hypoxic respiratory failure in preterm infants Shonola S Da-Silva1 and R Phillip Dellinger2 Section Head Pediatric Critical Care Medicine The Children s Regional Hospital Cooper University Medical Center UMDNJ-RWJ Medical School at Camden New Jersey USA 2Section Head Adult Critical Care Medicine Cooper University Medical Hospital UMDNJ-WJ Medical School at Camden New Jersey USA Correspondence Shonola S Da-Silva dasilva-shonola@ Published online 10 February 2004 Critical Care 2004 8 77-78 DOI cc2813 This article is online at http content 8 2 77 2004 BioMed Central Ltd Print ISSN 1364-8535 Online ISSN 1466-609X Abstract Acute hypoxic respiratory failure AHRF remains a significant cause of death in intensive care units. With the realization that pathophysiologic abnormalities in AHRF involve surfactant abnormalities as well as inflammatory and vascular changes it is not surprising that nitric oxide NO has been investigated as an adjunct to the multiple ventilatory strategies adopted in the management of this disorder. Since the enthusiastic reports of Roussaint in 1993 showing improved survival with inhaled NO in the management of AHRF several well-designed studies have been published all designed to investigate the utility of NO in neonatal pediatric and adult patients. Michael Schreiber and colleagues evaluated 207 preterm infants with AHRF in a randomized double-blind placebo-controlled study. Inhaled NO was administered at a constant low dose for up to 6 days in the NO group. Patients were further randomized to conventional ventilation and to high-frequency oscillatory ventilation. The patients showed a statistically significant improvement in their primary endpoint of the incidence of chronic lung injury and death in the inhaled NO group. There was no increase in the incidence of .
