Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Science review: Mechanisms of beta-receptor stimulationinduced improvement of acute lung injury and pulmonary edem a. | Critical Care August 2004 Vol 8 No 4 Groshaus et al. Review Science review Mechanisms of beta-receptor stimulation-induced improvement of acute lung injury and pulmonary edema Horacio E Groshaus Sanjay Manocha Keith R Walley and James A Russell Critical Care Research Laboratories St Paul s Hospital and University of British Columbia Vancouver British Columbia Canada Corresponding author James A Russell jrussell@ Published online 25 May 2004 This article is online at http content 8 4 234 2004 BioMed Central Ltd Critical Care 2004 8 234-242 DOI cc2875 Abstract Acute lung injury ALI and the acute respiratory distress syndrome are complex syndromes because both inflammatory and coagulation cascades cause lung injury. Transport of salt and water repair and remodeling of the lung apoptosis and necrosis are additional important mechanisms of injury. Alveolar edema is cleared by active transport of salt and water from the alveoli into the lung interstitium by complex cellular mechanisms. Beta-2 agonists act on the cellular mechanisms of pulmonary edema clearance as well as other pathways relevant to repair in ALI. Numerous studies suggest that the beneficial effects of beta-2 agonists in ALI include at least enhanced fluid clearance from the alveolar space anti-inflammatory actions and bronchodilation. The purposes of the present review are to consider the effects of beta agonists on three mechanisms of improvement of lung injury edema clearance anti-inflammatory effects and bronchodilation. This update reviews specifically the evidence on the effects of beta-2 agonists in human ALI and in models of ALI. The available evidence suggests that beta-2 agonists may be efficacious therapy in ALI. Further randomized controlled trials of beta agonists in pulmonary edema and in acute lung injury are necessary. Keywords acute lung injury acute respiratory distress syndrome alveolar fluid clearance beta-agonists Introduction Acute lung injury ALI and .
