Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Role of iron in anaemic critically ill patients: it’s time to investigate! | Critical Care October 2004 Vol 8 No 5 Piagnerelli and Vincent Commentary Role of iron in anaemic critically ill patients it s time to investigate Michael Piagnerelli1 and Jean-Louis Vincent2 1 Resident Department of Intensive Care Erasme Hospital Free University of Brussels Brussels Belgium 2Head Department of Intensive Care Erasme Hospital Free University of Brussels Brussels Belgium Corresponding author Michael Piagnerelli Published online 3 June 2004 This article is online at http content 8 5 306 2004 BioMed Central Ltd See Review page 356 Critical Care 2004 8 306-307 DOI cc2884 Abstract Anaemia is a common problem in critically ill patients admitted to intensive care units. Many factors can be involved in its development including rapid alterations in iron metabolism. Maintenance of iron homeostasis is a prerequisite for many essential biological processes and is a central element for the development of erythroid precursors and mature red blood cells. With the inflammatory process iron distribution is disturbed with decreased serum iron levels and increased iron stores. Little information is available on the precise role of alterations in iron metabolism in the development of iron anaemia in critically ill patients. Keywords anaemia erythropoietin iron red blood cell Anaemia is a major cause of morbidity and mortality worldwide and is often observed in critically ill patients not just at admission but particularly during intensive care unit ICU stay 1 . The time course of anaemia during an ICU stay depends on the underlying pathologies 1 but at least a third of ICU patients receive a transfusion at some point during their ICU stay 2 3 . The rationale behind blood transfusion is to restore oxygen delivery and provide a reserve should further bleeding occur. Several recent studies have modified transfusion practice in terms of the level of pretransfusion haemoglobin concentration 3 and in view of the adverse .
