Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Genetic epidemiology of acute lung injury: choosing the right candidate genes is the first step. | Available online http content 8 6 411 Commentary Genetic epidemiology of acute lung injury choosing the right candidate genes is the first step Jason D Christie Assistant Professor of Medicine and Assistant Professor of Epidemiology Division of Pulmonary and Critical Care Medicine Department of Medicine and the Department of Biostatistics and Epidemiology University of Pennsylvania School of Medicine Philadelphia Pennsylvania USA Corresponding author Jason D Christie jchristi@ Published online 19 August 2004 This article is online at http content 8 6 411 2004 BioMed Central Ltd See Review page 440 Critical Care 2004 8 411-413 DOI cc2931 Abstract In an innovative scientific review in this issue Grigoryev and colleagues report a method for choosing candidate genes for acute lung injury ALI based on gene expression data derived from multiple animal models of mechanical ventilation and shear stress. The authors conclude there are five key biologic processes that warrant further investigation inflammatory and immune responses cell proliferation chemotaxis and blood coagulation. This review represents an important first step toward studying the genetic epidemiology of ventilator-induced lung injury and ALI. The application of these findings to future human studies of the genetic influence on ALI risks and outcomes is discussed here. Keywords acute lung injury acute respiratory distress syndrome genetics genomics epidemiology translational research Introduction In recent years there has been growing interest in genetic susceptibility to acute lung injury ALI and in defining genetic determinants of outcomes in patients with established ALI 1 2 . The sporadic nature of ALI and the requirement for an extreme environmental predisposing insult such as sepsis or trauma make traditional family linkage studies of ALI unreasonable. Thus the study of genetic influence on ALI incidence and outcomes will involve gene association .
