Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Rhabdomyolysis – an overview for clinicians. | Critical Care April 2005 Vol 9 No 2 Huerta-Alardín et al. Review Bench-to-bedside review Rhabdomyolysis - an overview for clinicians Ana L Huerta-Alardín1 Joseph Varon2 and Paul E Marik3 1 Universidad Autónoma de Tamaulipas School of Medicine Tampico México 2The University of Texas Health Science Center and St Luke s Episcopal Hospital Houston Texas USA 3Thomas Jefferson University Hospital Philadelphia Pennsylvania USA Corresponding author Joseph Varon Published online 20 October 2004 This article is online at http content 9 2 158 2004 BioMed Central Ltd Critical Care 2005 9 158-169 DOI cc2978 See commentary page 141 http content 9 2 R141 and see related research by Naka et al. in this issue http content 9 2 R90 Abstract Rhabdomyolysis ranges from an asymptomatic illness with elevation in the creatine kinase level to a life-threatening condition associated with extreme elevations in creatine kinase electrolyte imbalances acute renal failure and disseminated intravascular coagulation. Muscular trauma is the most common cause of rhabdomyolysis. Less common causes include muscle enzyme deficiencies electrolyte abnormalities infectious causes drugs toxins and endocrinopathies. Weakness myalgia and tea-colored urine are the main clinical manifestations. The most sensitive laboratory finding of muscle injury is an elevated plasma creatine kinase level. The management of patients with rhabdomyolysis includes early vigorous hydration. Introduction Rhabdomyolysis means destruction or disintegration of striated muscle 1 . This syndrome is characterized by muscle breakdown and necrosis resulting in the leakage of the intracellular muscle constituents into the circulation and extracellular fluid 2 . Rhabdomyolysis ranges from an asymptomatic illness with elevation in the creatine kinase CK level to a lifethreatening condition associated with extreme elevations in CK electrolyte imbalances acute renal failure
