Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of magnesium sulfate administration on blood–brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study. | Available online http content 9 1 R18 Re search Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis a randomized controlled experimental study Figen Esen1 Tulin Erdem2 Damla Aktan2 Mukadder Orhan3 Mehmet Kaya4 Haluk Eraksoy5 Nahit Cakar1 and Lutfi Telci1 Open Access 1 Professor University of Istanbul Istanbul Faculty of Medicine Department of Anesthesiology and Intensive Care Istanbul Turkey 2Staff Anesthesiologist University of Istanbul Istanbul Faculty of Medicine Department of Anesthesiology and Intensive Care Istanbul Turkey 3MD University of Istanbul Istanbul Faculty of Medicine Department of Anesthesiology and Intensive Care Istanbul Turkey 4Professor University of Istanbul Istanbul Faculty of Medicine Department of Physiology Istanbul Turkey 5Professor University of Istanbul Istanbul Faculty of Medicine Department of Infectious Disease and Clinical Microbiology Istanbul Turkey Corresponding author Figen Esen esenf@ Received 1 September 2004 Revisions requested 23 September 2004 Revisions received 14 October 2004 Accepted 25 October 2004 Published 23 November 2004 Critical Care 2005 9 R18-R23 DOI cc3004 This article is online at http content 9 1 R18 2004 Esen et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Permeability changes in the blood-brain barrier BBB and their possible contribution to brain edema formation have a crucial role in the pathophysiology of septic encephalopathy. Magnesium sulfate has been shown to have a protective effect on BBB integrity in multiple experimental models. In this study we determine whether magnesium sulfate administration could have any protective effects
