Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Another piece in the puzzle. | Available online http content 9 1 27 Commentary Another piece in the puzzle Thomas S Maxey1 and William B Keeling2 1 Chief Resident General Surgery Department of Surgery University of South Florida College of Medicine Tampa Florida USA 2Senior Resident General Surgery Department of Surgery University of South Florida College of Medicine Tampa Florida USA Corresponding author Thomas S Maxey tjmaxey@ Published online 9 December 2004 This article is online at http content 9 1 27 2004 BioMed Central Ltd See Research by Van Putte et al. page 119 Critical Care 2005 9 27-28 DOI cc3019 Abstract Pulmonary ischemia-reperfusion injury is complex and involves many cell types and mechanisms of action. Van Putte and coworkers have attempted to provide insight into and describe some of the complex components of this process. Their study describes two new components of the multifaceted process of reperfusion injury. The time-dependent course of neutrophil activation and the discovery of programmed cell death in reperfused lung tissue are two new pieces of a complex puzzle. Keywords ischemia-reperfusion injury lung injury pulmonary The multifaceted phenomenon of pulmonary ischemia-reperfusion IR involves alveolar macrophages vascular endothelial cells circulating neutrophils adhesion factors free radicals and a wealth of cytokines. There is a large body of literature describing techniques to attenuate lung IR injury. To date however little attention has been focused on the specific mechanisms of lung IR injury itself. The complexity and amplification of the cascades involved in this phenomenon have made investigation of individual components of reperfusion injury difficult to assess. Characterization of the injury pattern during the early phase of reperfusion is limited. Van Putte and colleagues 1 have attempted to provide insight into and describe some of the key components of this process using a warm blood perfused model. Fiser and .
