Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Biotrauma and modulation of the innate immune response. | Critical Care June 2005 Vol 9 No 3 dos Santos et al. Review Bench-to-bedside review Biotrauma and modulation of the innate immune response Claudia C dos Santos1 Haibo Zhang2 Mingyao Liu3 and Arthur S Slutsky4 1 Clinical Associate and Post Doctoral Fellow Departments of Medicine and Critical Care Medicine St. Michael s Hospital and Inter-Departmental Division of Critical Care University of Toronto Toronto Ontario Canada 2Assistant Professor Departments of Medicine and Critical Care Medicine St. Michael s Hospital and Inter-Departmental Division of Critical Care University of Toronto Toronto Ontario Canada 3Professor Departments of Medicine and Critical Care Medicine St. Michael s Hospital and Inter-Departmental Division of Critical Care University of Toronto Toronto Ontario Canada 4Vice President of Research Departments of Medicine and Critical Care Medicine St. Michael s Hospital and Inter-Departmental Division of Critical Care University of Toronto Toronto Ontario Canada Corresponding author Arthur S Slutsky Published online 5 January 2005 This article is online at http content 9 3 280 2005 BioMed Central Ltd Critical Care 2005 9 280-286 DOI cc3022 Abstract The innate immune network is responsible for coordinating the initial defense against potentially noxious stimuli. This complex system includes anatomical physical and chemical barriers effector cells and circulating molecules that direct component and system interactions. Besides the direct effects of breaching pulmonary protective barriers cyclic stretch generated during mechanical ventilation MV has been implicated in the modulation of the innate immunity. Evidence from recent human trials suggests that controlling MV-forces may significantly impact outcome in acute respiratory distress syndrome. In this paper we explore the pertinent evidence implicating biotrauma caused by cyclic MV and its effect on innate immune responses. Introduction The natural or innate
