Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C. | Available online http content 9 3 R211 Research Tezosentan-induced attenuation of lung injury in endotoxemic sheep is associated with reduced activation of protein kinase C Vladimir Kuklin1 Mikhail Kirov1 Mikhail Sovershaev2 Thomas Andreasen3 Ole C Ingebretsen4 Kirsti Ytrehus5 and Lars Bjertnaes6 Research Fellow Department of Anesthesiology Faculty of Medicine University of Tromso Norway 2Research Fellow Department of Physiology Faculty of Medicine University of Tromso Norway departmental engineer Department of Physiology Faculty of Medicine University of Tromso Norway 4Professor Department of Clinical Chemistry University Hospital of Tromso Norway 5Professor Department of Physiology Faculty of Medicine University of Tromso Norway 6Professor Chairman of the Department of Anesthesiology Faculty of Medicine University of Tromso Norway Corresponding author Lars Bjertnaes Received 24 Nov 2004 Revisions requested 9 Jan 2005 Revisions received 27 Jan 2005 Accepted 16 Feb 2005 Published 14 Mar 2005 Critical Care 2005 9 R211-R217 DOI cc3497 This article is online at http content 9 3 R211 2005 Kuklin et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Studies in vitro reveal that endothelin-1 ET-1 activates the a isoform of protein kinase C PKC-a in cultures of endothelial cells thereby deranging cellular integrity. Sepsis and endotoxemia are associated with increased plasma concentrations of ET-1 that induce acute lung injury ALI . We recently reported that non-selective ET-1 receptor blockade attenuates ALI in sheep by reducing the endotoxin-induced increase in extravascular lung water index EVLWI . The aim of this study was to find out .
