Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Clinical review: Respiratory mechanics in spontaneous and assisted ventilation. | Critical Care October 2005 Vol 9 No 5 Grinnan and Truwit Review Clinical review Respiratory mechanics in spontaneous and assisted ventilation Daniel C Grinnan1 and Jonathon Dean Truwit2 1 Fellow Department of Pulmonary and Critical Care University of Virginia Health System Virginia USA 2E Cato Drash Professor of Medicine Senior Associate Dean for Clinical Affairs Chief Department of Pulmonary and Critical Care University of Virginia Health System Virginia USA Corresponding author Daniel C Grinnan dg6j@ Published online 18 April 2005 Critical Care 2005 9 472-484 DOI cc3516 This article is online at http content 9 5 472 2005 BioMed Central Ltd Abstract Pulmonary disease changes the physiology of the lungs which manifests as changes in respiratory mechanics. Therefore measurement of respiratory mechanics allows a clinician to monitor closely the course of pulmonary disease. Here we review the principles of respiratory mechanics and their clinical applications. These principles include compliance elastance resistance impedance flow and work of breathing. We discuss these principles in normal conditions and in disease states. As the severity of pulmonary disease increases mechanical ventilation can become necessary. We discuss the use of pressure-volume curves in assisting with poorly compliant lungs while on mechanical ventilation. In addition we discuss physiologic parameters that assist with ventilator weaning as the disease process abates. Introduction In humans ventilation involves movement of the chest wall to produce a pressure gradient that will permit flow and movement of gas. This can be accomplished by the respiratory muscles by negative pressure ventilation iron lung or by positive pressure ventilation mechanical ventilator . Measurements of respiratory mechanics allow a clinician to monitor closely the course of pulmonary disease. At the bedside changes in these mechanics can occur abruptly and prompt immediate action or they
