Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Randomized controlled trials are needed to determine appropriate blood transfusion strategies in patients with acute coronary syndromes. | Available online at http content 9 3 E6 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique Randomized controlled trials are needed to determine appropriate blood transfusion strategies in patients with acute coronary syndromes Stephanie Freeman1 and Michael A. DeVita2 1 Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Associate Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 18 March 2005 This article is online at http content 9 3 E6 2005 BioMed Central Ltd Critical Care 9 E6 DOI cc Expanded Abstract Citation Rao SV Jollis JG Harrington RA Granger CB Newby LK Armstrong PW Moliterno DJ Lindblad L Pieper K Topol EJ Stamler JS Califf RM Relationship of blood transfusion and clinical outcomes in patients with acute coronary syndromes. JAMA 2004 292 1555-1562 1 . Background It is unclear if blood transfusion in anemic patients with acute coronary syndromes is associated with improved survival. Objective To determine the association between blood transfusion and mortality among patients with acute coronary syndromes who develop bleeding anemia or both during their hospital course. Methods Design Retrospective cohort analysis of prospectively collected clinical trial data. Setting and Patients 24 112 patients from three large international trials of patients with acute coronary syndromes the GUSTO IIb PURSUIT and PARAGON B trials . Patients were grouped according to whether they received a blood transfusion during the hospitalization. The association between transfusion and outcome was assessed using Cox proportional hazards modeling that incorporated transfusion as a time-dependent covariate and the propensity to receive blood and a landmark analysis.
