Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Quantitative physico-chemical analysis of the acidosis of cardiac arrest. | Available online http content 9 4 347 Commentary Quantitative physico-chemical analysis of the acidosis of cardiac arrest Heatherlee Bailey Associate Program Director of Emergency Medicine Assistant Professor of Emergency Medicine Drexel University College of Medicine Philadelphia PA USA Corresponding author Heatherlee Bailey HBaileyMD@ Published online 22 July 2005 Critical Care 2005 9 347-348 DOI cc3770 This article is online at http content 9 4 347 2005 BioMed Central Ltd See related research by Makino et al. in this issue http content 9 4 R357 Abstract Metabolic acidosis is a common finding after cardiac arrest. Until recently this acidosis was mainly attributed to lactate. The physicochemical approach to acid-base balance permits the detection of previously unmeasured ions. These ions have been shown to affect the acid-base status of patients. Introduction The acid-base disturbance in patients suffering cardiac arrest is more complex than previously thought. Makino and colleagues have presented a quantitative assessment of the components that create the disturbance 1 . As previously reported hyperlactatemia is not the sole cause of metabolic acidosis in the patient after arrest 2 . The physico-chemical approach permits the detection of unmeasured ions and the measurement of their effect on the patient. The physico-chemical approach The authors present a concise review of the physico-chemical approach to acid-base balance using the Stewart-Figge methodology 3 4 . This concept is based on the principles of electric neutrality and the conservation of mass. There are three independent variables that determine blood pH partial pressure of CO2 pCO2 total weak acid concentration ATOT and the strong ion difference SID . pCO2 is an independent variable. Ions that are fully dissociated at physiologic pH are known as strong ions. The difference between the strong cations such as sodium and the strong anions such as .
