Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Steroid use in PROWESS severe sepsis patients treated with drotrecogin alfa (activated). | Available online http content 9 5 R502 Research Steroid use in PROWESS severe sepsis patients treated with drotrecogin alfa activated Howard Levy1 Pierre-Francois Laterre2 Becky Bates3 and Rebecca L Qualy4 1Medical Director Acute Care Eli Lilly and Co. Indianapolis Indiana USA 2Professor in Medicine Head of Intensive Care Medicine Critical Care and Emergency Department Cliniques Universitaires St Luc UCL Brussels Belgium 3Associate Senior Statistician Eli Lilly and Co. Indianapolis Indiana USA 4Senior Scientific Communications Associate Eli Lilly and Co. Indianapolis Indiana USA Corresponding author Howard Levy hlevy@ Received 2 May 2005 Revisions requested 25 May 2005 Revisions received 9 Jun 2005 Accepted 1 Jul 2005 Published 27 Jul 2005 Critical Care 2005 9 R502-R507 DOI 86 cc3778 This article is online at http content 9 5 R502 2005 Levy et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction In a study conducted by Annane patients with septic shock and unresponsive to adrenocorticotropic hormone stimulation receiving low-dose steroid therapy had prolonged survival but not significantly improved 28-day mortality. The present study examines intravenous steroid use in PROWESS Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis patients meeting the Annane enrollment criteria AEC . Methods Adrenocorticotropic hormone stimulation tests were not done in PROWESS. Steroids were allowed but their use was not directed. Patients were identified using AEC all of randomization to study drug treatment within 8 hours of shock onset infection fever or hypothermia tachycardia systolic blood pressure 90 mmHg on vasopressors mechanical .
