Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation. | Available online http content 9 6 R653 Research Early hemoperfusion with an immobilized polymyxin B fiber column eliminates humoral mediators and improves pulmonary oxygenation Hidehiko Kushi1 Takahiro Miki2 Kazuhiko Okamaoto2 Jun Nakahara1 Takeshi Saito1 and Katsuhisa Tanjoh1 Department of Emergency and Critical Care Medicine Nihon University School of Medicine 30-1 Oyaguchi Kamimachi Itabashi-ku Tokyo 1738610 Japan 2Department of Clinical Engineering Surugadai Nihon University Hospital 1-8-13 Kanda Surugadai Chiyoda-ku Tokyo 101-8309 Japan Corresponding author Hidehiko Kushi hkushi@ Received 29 Jun 2005 Revisions requested 4 Aug 2005 Revisions received 25 Aug 2005 Accepted 1 Sep 2005 Published 11 Oct 2005 Critical Care 2005 9 R653-R661 DOI 86 cc3815 This article is online at http content 9 6 R653 2005 Kushi et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The objective of this study was to clarify the efficacy and mechanism of action of direct hemoperfusion with an immobilized polymyxin B fiber column DHP-PMX in patients with acute lung injury or acute respiratory distress syndrome caused by sepsis. Method Thirty-six patients with sepsis were included. In each patient a thermodilution catheter was inserted and the oxygen delivery index and oxygen consumption index were measured. DHP-PMX was performed in patients with a normal oxygen delivery index and oxygen consumption index 500 ml minute per m2 and 120 ml minute per m2 respectively . The Acute Physiology and Chronic Health Evaluation II score was used as an index of the severity of sepsis and survival was assessed after 1 month. The humoral mediators measured were the chemokine IL-8 .
