Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Higher initial tidal volumes associated with the subsequent development of acute lung injury in dose-response relationship. | Available online at http content 9 6 E25 University of Pittsburgh Department of Critical Care Medicine Evidence-Based Medicine Journal Club EBM Journal Club Section Editor Eric B. Milbrandt MD MPH Journal club critique Higher initial tidal volumes associated with the subsequent development of acute lung injury in dose-response relationship Luxmi Gahlot 1 Eric B. Milbrandt 2and James Snyder3 1 Clinical Fellow Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 2 Assistant Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA 3 Professor Department of Critical Care Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA Published online 20 October 2005 This article is online at http ccforum content 9 6 E25 2005 BioMed Central Ltd Critical Care 9 E25 DOI cc3897 Expanded Abstract Citation Gajic O Dara SI Mendez JL Adesanya AO Festic E Caples SM Rana R St Sauver JL Lymp JF Afessa B Hubmayr RD Ventilator-associated lung injury in patients without acute lung injury at the onset of mechanical ventilation. Crit Care Med 2004 32 1817-1824 1 . Objective Although ventilation with small tidal volumes is recommended in patients with established acute lung injury most others receive highly variable tidal volume aimed in part at normalizing arterial blood gas values. We tested the hypothesis that acute lung injury which develops after the initiation of mechanical ventilation is associated with known risk factors for ventilator-induced lung injury such as ventilation with large tidal volume. Methods Design Retrospective cohort study. Setting Four intensive care units in a tertiary referral center. Subjects 332 patients who received invasive mechanical ventilation for 48 hrs between January and December 2001. Intervention None. Measurements The main outcome of interest acute lung injury was assessed by independent .
