Retrovirology Short report BioMed Central Open Access Increased neutrophil apoptosis in

Retrovirology Short report BioMed Central Open Access Increased neutrophil apoptosis in chronically SIV-infected macaques Carole Elbim1, Valérie Monceaux2, Stéphanie François3, Bruno Hurtrel2, Marie-Anne Gougerot-Pocidalo3 and Jérome Estaquier*2,4,5 Address: 1Centre de Recherche des Cordeliers, Université Pierre et Marie Curie – Paris 6, UMR S 872, Paris, F-75006 France; Université Paris Descartes, UMR S 872, Paris, F-75006, France, 2Institut Pasteur, Unité de Physiopathologie des Infections Lentivirales, Paris, F-75015, France, 3APHP, Centre Hospitalier Universitaire Xavier Bichat, Service d'Immunologie et d'Hématologie, Paris, F-75018, France, 4INSERM, U841, Faculté de Médecine de Créteil, Créteil, F-94010, France and 5AP-HP, Hôpital Henri Mondor, Créteil, F-94010, France Email: Carole Elbim - ; Valérie Monceaux -. | Retrovirology BioMed Central Short report Increased neutrophil apoptosis in chronically SIV-infected Open Access macaques Carole Elbim1 Valérie Monceaux2 Stephanie Francois3 Bruno Hurtrel2 Marie-Anne Gougerot-Pocidalo3 and Jérome Estaquier 2 4 5 Address 1Centre de Recherche des Cordeliers Université Pierre et Marie Curie - Paris 6 UMR S 872 Paris F-75006 France Université Paris Descartes UMR S 872 Paris F-75006 France 2Institut Pasteur Unite de Physiopathologie des Infections Lentivirales Paris F-75015 France 3AP-HP Centre Hospitalier Universitaire Xavier Bichat Service d lmmunologie et d Hematologie Paris F-75018 France 4INSERM U841 Faculte de Medecine de Creteil Créteil F-94010 France and 5AP-HP Hôpital Henri Mondor Creteil F-94010 France Email Carole Elbim - Valerie Monceaux - Stephanie Francois - francois@ Bruno Hurtrel - Marie-Anne Gougerot-Pocidalo - Jerome Estaquier - estaquier@ Corresponding author Published 24 March 2009 Received 14 November 2008 Retrovirology 2009 6 29 doi 1742-4690-6-29 Accepted 24 March 2009 This article is available from http content 6 1 29 2009 Elbim et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Polymorphonuclear neutrophils PMN from chronically HIV-infected individuals have been reported to be more prone to die. However although non-human primates models have been extensively used for improving our knowledge on T cell immunity the impact of SIV-infection on PMN in relationships with disease severity has never been assessed. In our study we demonstrate that PMN from Rhesus macaques RMs of Chinese origin chronically .