Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Retrovirology Research cung cấp cho các bạn kiến thức về ngành y đề tài:"TLR2 and TLR4 triggering exerts contrasting effects with regard to HIV-1 infection of human dendritic cells and subsequent virus transfer to CD4+ T cells. | Retrovirology BioMed Central Research TLR2 and TLR4 triggering exerts contrasting effects with regard to HIV-1 infection of human dendritic cells and subsequent virus transfer to CD4 T cells Sandra Thibault1 2 Rémi Fromentin1 2 Mélanie R Tardif1 2 and Michel J Tremblay 1 2 Open Access Address 1Faculté de Médecine Université Laval Quebec Canada and 2Centre de Recherche en Infectiologie Centre Hospitalier de l Université Laval Quebec Canada Email Sandra Thibault - Rémi Fromentin - Mélanie R Tardif - Michel J Tremblay - Corresponding author Published 6 May 2009 Received 12 December 2008 Retrovirology 2009 6 42 doi 1742-4690-6-42 Accepted 6 May 2009 This article is available from http content 6 1 42 2009 Thibault et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Recognition of microbial products through Toll-like receptors TLRs initiates inflammatory responses orchestrated by innate immune cells such as dendritic cells DCs . As these cells are patrolling mucosal surfaces a portal of entry for various pathogens including human immunodeficiency virus type-1 HIV-1 we investigated the impact of TLR stimulation on productive HIV-1 infection of DCs and viral spreading to CD4 T cells. Results We report here that engagement of TLR2 on DCs increases HIV-1 transmission toward CD4 T cells by primarily affecting de novo virus production by DCs. No noticeable and consistent effect was observed following engagement of TLR5 7 and 9. Additional studies indicated that both HIV-1 infection of DCs and DC-mediated virus transmission to CD4 T cells were reduced upon
