Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Do statins have a role in preventing or treating sepsis? | Available online http content 10 1 113 Commentary Do statins have a role in preventing or treating sepsis Victor Novack1 Marius Terblanche2 and Yaniv Almog3 Senior Physician Medical Intensive Care Unit Soroka University Medical Center Faculty of Health Sciences Ben Gurion University of the Negev Beer-Sheva Israel 2Clinical Fellow Critical Care Medicine Sunnybrook Women s College Health Sciences Centre Toronto Ontario Canada 3Director Medical Intensive Care Unit Soroka University Medical Center Faculty of Health Sciences Ben Gurion University of the Negev Beer-Sheva Israel Corresponding author Yaniv Almog almogya@ Published 23 January 2006 This article is online at http content 10 1 113 2006 BioMed Central Ltd Critical Care 2006 10 113 doi cc3972 Abstract Statins have a variety of properties that are independent of their lipid lowering ability. These anti-inflammatory antioxidant immunomodulatory and antiapoptotic features have been collectively referred to as pleiotropic effects. Severe sepsis is an intense infection-induced inflammatory syndrome that ultimately results in organ dysfunction. Because so many cascades are triggered during sepsis merely blocking a single component may be insufficient to arrest the inflammatory process. A growing body of evidence suggests that statins may indeed have a protective effect against severe sepsis and reduce the rate of infection-related mortality. This novel primary prevention concept may have far-reaching implications for the future management of serious infections. Moreover it was recently shown that statins potentially improve outcome after the onset of sepsis. The stage is now set for randomized clinical trials that will determine the precise role if any that statins may have in preventing and treating sepsis. Severe sepsis is an infection-induced inflammatory syndrome that ultimately leads to organ dysfunction. It is estimated that more than 500 000 episodes of sepsis occur each
